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CIP Modules


CLEANING IN PLACE (CIP) Module is the process used to ensure that, process reactors, vessels and lines are free of organic and inorganic contaminants:

Pharmaceuticals
  • Sterile Solutions
  • Vial
  • Ampoules
  • I. V. Fluids
  • Aerosols
  • LVP & SVP Solutions
Biopharmaceuticals
  • Vaccines
  • Human Insulin
  • Serums
  • Plasma Fractions
  • Bacteria & cell cultures

CIP cycles can be subjected to the following process machinery

  • Fermentors
  • Blending Vessels
  • Media / Harvest / Storage / Filtration Vessels
  • Transfer Lines
  • Process Equipment

CIP Module for Processing Vessels ranging from 50 litres to 30000 litres

  • Completely Automated Process Cycles
  • On line display of process parameters with P & I of Operating Systems
  • Display of Fault messages
  • Supervisory access code prevent unauthorized changes
  • Detergent / Acid / Alkali dosing
  • On Line pH, Conductivity, TOC Sensing
  • CIP is designed in accordance with ASME BPE and EHEDG guidelines
  • PLC-based, with Touch Screen MMI and SCADA Packages

Spray device characteristics

  • The cleaning liquid turns the spray head by means of a specially positioned nozzle
  • Rapid repitition impact loosens the dirt and washes it off the tank surface
  • The cleaning effects is optimum at low pressure in small to medium size tanks
  • With increasing pressure, the rotation speed gets higher, while due to stronger atomization, the reach of the spray gets lower
  • Operation at the optimum pressure ensures required cleaning results and avoids wear of the nozzle

Effective Cleaning Criteria Factors include

  • Cleaning Cycle Time
  • Cleaning Agent and Temperature
  • Concentration and Chemistry of the Cleaning Agent within the circuit
  • Degree of Turbulence of the Cleaning Solution
  • Characteristics of the surface being cleaned
  • Spray Device Selection (Static Dynamic)
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Key Benefits
  • Validatable process for Sterilization of process equipment
  • Lower Facility Operating Costs
  • Minimal dismantling of equipment and piping
  • Reduced turnaround time for cleaning
  • WFI requirement for cleaning reduced significantly
  • Exposure to hazardous activities or entry into tanks, is eliminated

CIP Module for Processing Vessels ranging from 50 litres to 30000 litres